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. 2019 Sep 7;25(33):4904–4920. doi: 10.3748/wjg.v25.i33.4904

Figure 2.

Figure 2

Liver biopsy-confirmed non-alcoholic fatty liver disease activity score and fibrosis scores in ob/ob mice fed amylin liver non-alcoholic steatohepatitis (AMLN) or Gubra amylin non-alcoholic steatohepatitis (GAN) diet for 16 wk. A: Representative images of terminal liver morphology (upper panel: hematoxylin-eosin staining, lower panel: Picro-Sirus red staining, 20× magnification, scale bar 100 µm); B: Number of animals with higher, same or lower post-biopsy histopathology score compared to corresponding pre-biopsy score (n = 8-10 mice per group). Left panel: Non-alcoholic fatty liver disease activity score (NAS); right panel: Fibrosis score; C: Individual pre-biopsy and terminal NAS and fibrosis scores. AMLN: Amylin liver non-alcoholic steatohepatitis diet; GAN: Gubra amylin non-alcoholic steatohepatitis diet; NAFLD: Non-alcoholic fatty liver disease; NAS: Non-alcoholic fatty liver disease activity score.