Table 4.

Clinical characteristics related to PER.

Exposure to adjunctive therapy	Syndrome classificationa	Type of seizures	Seizure frequency before PER	Seizure frequency after PER
Yes	GTCA	Tonic–clonic	Once every eight weeks	Zero
Yes	JME	Tonic–clonic Myoclonic	Once every two months Three times per week	Zero
Yes	JME	Tonic–clonic Myoclonic	Once per month Once per week	Zero
Yes	JME	Myoclonic	Four times daily	Zero
Yes	JME	Tonic–clonic Myoclonic Absence Atonic	Twice per week Four times daily Once daily Once per week	Once per week Once per day Once every three weeks Once per month
Yes	JME	Tonic–clonic Myoclonic	Once every three months Four times per day	Zero Once per day
Yes	JME	Myoclonic	Twice per day	Once every two weeks
No	JME	Tonic–clonic	Once per month	Zero
Yes	JME	Myoclonic	Four times per day	Zero
Yes	JME	Tonic–clonic Myoclonic	Once per month Two–three times per day	Zero Zero
No	JME	Tonic–clonic Myoclonic	Once every two months Three times per week	Zero Zero
Yes	JME	Tonic–clonic Myoclonic	Three–four per week Three–four per day	Once per week Twice per week
Yes	JME	Tonic–clonic Myoclonic	Once per week Three times per week	Once every two months Once every two weeks
Yes	JME	Tonic–clonic Myoclonic	Once every two weeks Once daily	Once every six–eight weeks Once every seven–ten days
Yes	JME	Tonic–clonic Myoclonic	Once every three–four months Two–three times per week	Zero Zero
Yes	JAE	Tonic–clonic Absence	Once per week Once daily	Zero Zero
Yes	GTCA	Tonic–clonic	Once per month	Once every two–three months
Yes	GTCA	Tonic–clonic	Twice per month	Once every two–three months
Yes	JME	Tonic–clonic Myoclonic	Once per month Once or twice per week	Discontinued due to AE
Yes	JTCA	Tonic–clonic	Twice per month	Zero
Yes	JME	Tonic–clonic Myoclonic	Two–three times per month Three–four times per week	Discontinued due to AE

^aGTCA — generalized tonic–clonic seizures alone; JME — juvenile myoclonic epilepsy; JAE — juvenile absence epilepsy.