Table 2.
Descriptions of model variables and parameters with units. *Immune response corresponds to myeloid infiltration
| Output | Description | Units |
|---|---|---|
|
Tumour volume | cm
|
|
Fraction of immune response* in tumour | unitless |
|
Fraction of vascular delivery in tumour | unitless |
|
Fraction of necrosis in tumour | unitless |
|
Fraction of hypoxia in tumour | unitless |
| Parameter Symbol | Description | Units |
|
Tumour volume growth rate | 1/day |
|
Ability of hypoxia to promote tumour growth | unitless |
|
Rate tumour volume decreases due to immune response | 1/day |
|
Rate immune response increases due to necrosis | 1/day |
|
Rate immune response increases due to vascular delivery | 1/day |
|
Rate immune response decreases per tumour volume | 1/(cm day) |
|
Rate vascular delivery increases per tumour volume | 1/(cm day) |
|
Rate vascular delivery increases due to immune response | 1/day |
|
Rate vascular delivery decreases per tumour volume | 1/(cm day) |
|
Rate of increased necrosis due to decreased vascular delivery | 1/day |
|
Rate necrosis decreases due to immune response | 1/day |
|
Rate of hypoxia increases/decreases due to vascular delivery | 1/day |
|
Hypoxia increase/decrease threshold due to vascular delivery | unitless |