Table 4.

Risks factors for graft failure, grade II-IV acute and chronic GVHD

Outcomes	Events/evaluable	HR (95% CI)	P
Graft failure
Age at transplantation, y
≤6	49/638	1.00	.02
7-15	43/439	1.30 (0.86-1.96)	.21
16-25	7/33	3.03 (1.36-6.73)	.006
Donor type
HLA-matched relative	58/677	1.00	<.001
HLA-mismatched relative	17/78	2.84 (1.65-4.88)	<.001
HLA-matched unrelated	13/252	0.61 (0.33-1.11)	.10
HLA-mismatched unrelated	11/103	1.31 (0.68-2.50)	.42
Acute GVHD
Age at transplantation, y
≤6	93/634	1.00	.002
7-15	78/436	1.10 (0.71-1.70)	.66
16-25	10/33	2.23 (1.30-3.84)	.003
Donor type
HLA-matched relative	80/674	1.00	<.001
HLA-mismatched relative	27/77	3.33 (2.15-5.17)	<.001
HLA-matched unrelated	54/251	2.44 (1.72-3.46)	<.001
HLA-mismatched unrelated	20/101	1.94 (1.19-3.16)	.008
Transplant period
2012-2016	85/653	1.00	<.001
2006-2011	68/338	1.70 (1.23-2.35)	.001
2000-2005	28/112	2.50 (1.61-4.00)	<.001
Chronic GVHD
Donor type
HLA-matched relative	52/627	1.00	<.001
HLA-mismatched relative	14/70	2.64 (1.42-4.89)	.002
HLA-matched unrelated	21/249	2.13 (1.13-4.00)	.02
HLA-mismatched unrelated	24/101	4.25 (2.43-7.44)	<.001
Conditioning regimen
Bu/Cy/TT/FLU	17/372	1.00	<.001
Bu/Cy/FLU	24/255	2.03 (1.09-3.78)	.03
Bu/Cy	41/223	6.78 (3.59-12.81)	<.001
Treosulfan/TT/FLU	20/140	7.25 (3.41-15.41)	<.001
Bu or melphalan ± TT ± FLU	9/57	1.94 (0.82-4.60)	.13
Recipient sex
Male	82/659	1.00
Female	29/388	0.59 (0.38-0.91)	.02