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Reduction of anti-AAV5 NAB levels after IA procedure. (A). Levels of anti-AAV5 NAB (IC50) levels are reported at baseline (day 0), after rAAV5-hSEAP administration (day 49, NHPs 1-6), after IA (post IA, NHPs 4-6) and after rAAV5-hFIX readministration (day 77, NHPs 1-6). (B). Fold-decrease in anti-AAV5 NAB (IC50) levels measured in plasma samples taken after every cycle of the IA procedure.
