Depletion of nonmalignant lymphocytes during venetoclax-obinutuzumab treatment. Lymphocyte analysis in PB of patients at baseline (n = 36), after preinduction with obinutuzumab (n = 5), and after 1 year of treatment with venetoclax-obinutuzumab (n = 11) by flow cytometry. Absolute number of B cells (A) and CD4+ and CD8+ T cells (B) in PB. (C) Absolute number of NK (CD56bright and CD16+) cells in PB (baseline, n = 20). (D) Ratio of CD56bright (CD56brightCD16−)/CD56dim (CD56dimCD16+) cells (baseline, n = 6). Horizontal lines indicate reference values. *P < .05, **P < .01, 1-way ANOVA followed by Sidak’s multiple-comparisons test.