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. 2018 Nov 22;45(5):1012–1023. doi: 10.1093/schbul/sby163

Fig. 6.

Fig. 6.

The GABA enhancer diazepam elevates GABAergic responses and reverses some behavioral abnormalities in stressed D4KO mice. (A) Input-output curves of GABAAR-IPSC in prefrontal cortex (PFC) pyramidal neurons from wild-type (WT) or stressed D4KO mice injected with saline (KO+S+sal, n = 15 cells) or diazepam (KO+S+DZ, n = 11 cells). Inset: representative GABAAR-IPSC traces. (B) Bar graphs of spontaneous IPSC amplitude and frequency in PFC pyramidal neurons from stressed D4KO mice injected with saline (KO+S+sal, n = 11 cells) or DZ (KO+S+DZ, n = 16 cells). Inset: representative sIPSC traces. (C) Plot of basal startle response to different acoustic stimulus intensities in WT mice injected with saline (WT+sal, n = 5) or diazepam (WT+DZ, n = 4), or stressed D4KO mice injected with saline (KO+S+sal, n = 9) or diazepam (KO+S+DZ, n = 12). (D) Plot of PPI with the pre-pulse intensity of 70, 76 and 85 dB in the 4 groups. (E) Plot of discrimination ratio in TOR tests of WT+sal (n = 5), KO+S+sal (n = 9), and KO+S+DZ (n = 12) mice. (F) Plot of time in the open arm of elevated plus maze test from WT+sal (n = 5), KO+S+sal (n = 9) and KO+S+DZ (n = 12) mice. (G) Plot of social contact time and social approach numbers in the social engagement test of WT+sal (n = 5), KO+S+sal (n = 6) and KO+S+DZ (n = 6) mice. (H, I) Plot of the latency to fall in the rotarod test (H) and total moving distance within 10 and 30 min of the locomotion test (I) from the 3 groups. (A, D, E, F, G): *P < .05, **P < .01; ANOVA. (B): ***P < .001, unpaired t test.