Comparison 1. Single dose.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Weight (kg)	14	4970	Mean Difference (Random, 95% CI)	0.23 [0.05, 0.42]
1.1 High burden	8	1221	Mean Difference (Random, 95% CI)	0.57 [0.08, 1.06]
1.2 Intermediate burden	2	873	Mean Difference (Random, 95% CI)	0.11 [‐0.16, 0.39]
1.3 Low burden	4	2876	Mean Difference (Random, 95% CI)	‐0.05 [‐0.13, 0.04]
2 Height (cm)	10	2621	Mean Difference (IV, Random, 95% CI)	0.04 [‐0.14, 0.23]
2.1 High burden	6	874	Mean Difference (IV, Random, 95% CI)	0.20 [‐0.00, 0.40]
2.2 Intermediate burden	1	191	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐0.47, 0.07]
2.3 Low burden	3	1556	Mean Difference (IV, Random, 95% CI)	‐0.26 [‐0.74, 0.21]
3 Mid‐upper arm circumference (cm)	7	1307	Mean Difference (IV, Random, 95% CI)	0.19 [‐0.04, 0.41]
3.1 High burden	5	603	Mean Difference (IV, Random, 95% CI)	0.32 [0.06, 0.57]
3.2 Intermediate burden	1	482	Mean Difference (IV, Random, 95% CI)	0.19 [‐0.01, 0.40]
3.3 Low burden	1	222	Mean Difference (IV, Random, 95% CI)	‐0.3 [‐0.52, ‐0.08]
4 Triceps skin fold thickness (mm)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 High burden	3	352	Mean Difference (IV, Random, 95% CI)	1.34 [0.72, 1.97]
5 Subscapular skin fold thickness (mm)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 High burden	2	339	Mean Difference (IV, Fixed, 95% CI)	1.29 [1.13, 1.44]
6 Body mass index	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
6.1 High burden	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Haemoglobin (g/dL)	5	1252	Mean Difference (IV, Random, 95% CI)	0.10 [‐0.03, 0.22]
7.1 High burden	2	247	Mean Difference (IV, Random, 95% CI)	0.10 [‐0.65, 0.86]
7.2 Intermediate burden	2	658	Mean Difference (IV, Random, 95% CI)	0.06 [‐0.06, 0.17]
7.3 Low burden	1	347	Mean Difference (IV, Random, 95% CI)	0.06 [‐0.24, 0.36]