Kloetzel 1982.
Methods | RCT Length of follow‐up: 10 months |
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Participants | All children living in endemic area Number analysed for primary outcome: 337; unclear how many randomized Age range: 1 to 8 years old Inclusion criteria: enlisted from 9 rural communities in Pariquera‐Acu state of Sao Paulo Exclusion criteria: none stated |
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Interventions | Single dose vs placebo
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Outcomes |
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Notes | Location: Cameroon Burden: high Results reported as changes in nutritional status grouped into 3 categories: improved, deteriorated, no change (unclear on basis of which parameter), and proportions compared Source of funding: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "Randomized", no further details provided. |
Allocation concealment (selection bias) | Unclear risk | No details reported. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Described as double‐blind, no details reported. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No details about losses to follow‐up reported; quote: "the present report only deals with those 337 that could be followed throughout the entire 10 months". Inclusion of all randomized participants (number evaluable/number randomized): unclear (337 analysed). |
Selective reporting (reporting bias) | Low risk | All stated outcomes reported. |
Other bias | Low risk | No obvious other sources of bias. |