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. 2019 Sep 11;2019(9):CD000371. doi: 10.1002/14651858.CD000371.pub7

Sternberg 1997 (Screened).

Methods RCT
Length of follow‐up: 2.3 months (10 weeks)
Participants Infected children identified by screening
Number analysed for primary outcome: 133
Age range/mean age: 10.25 years
Inclusion criteria: children in Grades 4 and 5 in nine primary schools in central Jamaica with mild to‐moderate infections of T. Trichiura (> 1200 eggs per g of stool)
Exclusion criteria: none reported
Interventions Single dose vs placebo
  • Albendazole: 400 mg daily for 2 days

  • Placebo: identical

Outcomes Cognitive tests: two tests of perceptual speed; motor speed using grooved pegboard test‐dominant/nondominant hand; memory using free recall, digit span forward/backwards; reasoning using verbal analogies and figural series completions.
Not included in the review: stool egg counts at baseline and 10 weeks; socioeconomic status.
Outcomes not reported: height, weight and BMI (measured at baseline and end of study, only reported at baseline).
Notes Location: Jamaica
Burden: high
There was an infected placebo group and an quote: "uninfected control group"
Source of funding: James S. McDonnell Foundation.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: “The infected children were paired by sex within each class. If no match was available within the same class, then a child from the same grade of the school was chosen. The children in each pair were then randomly assigned to either treatment or placebo group.”
Allocation concealment (selection bias) Unclear risk No details reported.
Blinding (performance bias and detection bias) 
 All outcomes Low risk Quote: “control groups received inert placebo tablets, which looked identical to the albendazole ones”
Quote: “These tests were administered individually in the order in which they are listed above by one of two testers, who was unaware of the child's group assignment.”
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No children were lost to follow‐up.
Inclusion of all randomized participants (number evaluable/number randomized): 100% (133/133).
Selective reporting (reporting bias) High risk Quote: “All children had their heights and weights measured on enrollment and at the end of the study.”
Height and weight only reported at baseline.
Other bias Low risk No other obvious source of bias.