Sternberg 1997 (Screened).
Methods | RCT Length of follow‐up: 2.3 months (10 weeks) |
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Participants | Infected children identified by screening Number analysed for primary outcome: 133 Age range/mean age: 10.25 years Inclusion criteria: children in Grades 4 and 5 in nine primary schools in central Jamaica with mild to‐moderate infections of T. Trichiura (> 1200 eggs per g of stool) Exclusion criteria: none reported |
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Interventions | Single dose vs placebo
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Outcomes | Cognitive tests: two tests of perceptual speed; motor speed using grooved pegboard test‐dominant/nondominant hand; memory using free recall, digit span forward/backwards; reasoning using verbal analogies and figural series completions. Not included in the review: stool egg counts at baseline and 10 weeks; socioeconomic status. Outcomes not reported: height, weight and BMI (measured at baseline and end of study, only reported at baseline). |
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Notes | Location: Jamaica Burden: high There was an infected placebo group and an quote: "uninfected control group" Source of funding: James S. McDonnell Foundation. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: “The infected children were paired by sex within each class. If no match was available within the same class, then a child from the same grade of the school was chosen. The children in each pair were then randomly assigned to either treatment or placebo group.” |
Allocation concealment (selection bias) | Unclear risk | No details reported. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Quote: “control groups received inert placebo tablets, which looked identical to the albendazole ones” Quote: “These tests were administered individually in the order in which they are listed above by one of two testers, who was unaware of the child's group assignment.” |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No children were lost to follow‐up. Inclusion of all randomized participants (number evaluable/number randomized): 100% (133/133). |
Selective reporting (reporting bias) | High risk | Quote: “All children had their heights and weights measured on enrollment and at the end of the study.” Height and weight only reported at baseline. |
Other bias | Low risk | No other obvious source of bias. |