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aReagents and conditions: (a) (i) substituted aryl boronic acid, Pd(PPh3)4, 2.0 M aqueous K2CO3, DME, 80 °C, 6 h; (b) 2.0 M HCl in Et2O, CH2Cl2, rt, 18 h; (c) (i) PtO2, H2 (1 atm), HOAc, EtOAc, rt, 72 h; (ii) 2.0 M HCl in Et2O, CH2Cl2, rt, 18 h; (d) 44, HBTU, Et3N, i-Pr2NEt, rt, 16 h; (e) Zn(CN)2, Pd(PPh3)4, DMF, 130 °C (microwave irradiation), 30 min.
