Table 1.
Baseline and follow-up of biochemical and hormonal parameters.
| Laboratory parameter (units) (normal range) | Baseline1 | 1 month | 3 months2 | 9 months3 | 12 months | 18 months4 |
|---|---|---|---|---|---|---|
| Serum creatinine (mg/dl) (0.5-1.1) | 0.56 | 0.54 | 0.51 | 0.7 | 0.82 | 0.52 |
| Serum total calcium (mg/dl) (8.2-10.2) | 11.1 | 10.6 | 10.5 | 9.7 | 9.6 | 9.1 |
| Albumin (g/dl) (3-5) | 4.3 | 4.1 | 4.1 | 4.2 | 4.4 | |
| Serum phosphate (mg/dl) (2.7-4.5) | 1.8 | 2.1 | 1.5 | 1.8 | 1.5 | 1.5 |
| Serum magnesium (mg/dl) (1.7-2.6) | 2.1 | 1.8 | 2 | |||
| Alkaline phosphatase (µIU/l) (60-120) | 95 | 89 | 106 | 77 | 63 | |
| iPTH (pg/ml) (10-65) | 721 | 554 | 358 | 62 | 57 | 51 |
| 25(OH)D (ng/ml) (30-50) | 15 | 19 | 22.8 | 24 | ||
| 1,25 (OH)2D (pg/ml) (16-42) | 35 | |||||
| 24-h urinary calcium (mg) (100-300) | 114 | 293 | ||||
| 24-h urinary phosphate (mg) (400-1500) | 1690 |
Abbreviations: iPTH: intact parathyroid hormone; 25(OH)D: 25-hydroxy-vitamin D; 1,25(OH)2D: 1-25-dihydroxy-vitamin D.
Notes:
1. Treatment consisted of alphacalcidol 0.5 µg/day & phosphate 5 g/day
2. Cinacalcet 30 mg b.i.d., alphacalcidol 1.5 µg/day, phosphate 1 g q.i.d.,
3. Immediate post-parathyroidectomy biochemical pattern
4. Alphacalcidol 1.5 µg/day, phosphate 1 g b.i.d.