Table 3.

Study 3 design and efficacy of oral moxidectin against Dirofilaria immitis (ZoeMO)

Groupa (n = 5)	Treatmentb	Dosage (µg/kg)	Days of treatment	No. of dogs with worms	Adult D. immitis worm countsc
					Individual worm counts	Geometric meand	% reduction
T01	Placebo	N/A	0, 28, 56	5 of 5	23, 31, 31, 34, 36	30.7e	–
T02	Moxidectin	3	0	5 of 5	2, 3, 5, 9, 15	5.5f	82.1
T03	Moxidectin	24	0, 28, 56	1 of 5	1	0.1g	99.5
T04	Moxidectin	40	0, 28, 56	0 of 5	0	0g	100
T05	Moxidectin	60	0, 28, 56	0 of 5	0	0g	100

^aAll dogs were inoculated with 50 D. immitis L3 (ZoeMO strain) at Day − 28

^bMoxidectin administered as ProHeart^® tablets shaved to deliver the correct dose

^cAll dogs were necropsied for recovery and enumeration of adult heartworms on Day 120 (148 days post-inoculation)

^dMeans with different superscript letters (e–g) are significantly different (7.34 ≤ t₍₁₆₎ ≤ 16.0, P < 0.0001)

Abbreviation: na, not applicable