Table 5.

Top 20 IPA Canonical Pathways by time point for control versus pool sequential/simultaneous

Ingenuity canonical pathways	−log (p value)	Ratio
3 months
GDP-l-fucose Biosynthesis I (from GDP-d-mannose)	1.89	0.500
Methylmalonyl pathway	1.59	0.250
2-Oxobutanoate degradation I	1.49	0.200
PI3K/AKT signaling	1.33	0.024
GM-CSF signaling	1.08	0.027
Colanic acid building blocks biosynthesis	1.06	0.071
Wnt/β-catenin signaling	1.01	0.018
Mitochondrial l-carnitine shuttle pathway	0.98	0.059
Bladder cancer signaling	0.96	0.023
GADD45 signaling	0.93	0.053
Acute myeloid leukemia signaling	0.92	0.022
Inflammasome pathway	0.91	0.050
Pyrimidine deoxyribonucleotides de novo biosynthesis I	0.85	0.044
Estrogen-mediated S-phase entry	0.81	0.039
Sonic hedgehog signaling	0.76	0.035
Sperm motility	0.73	0.017
LXR/RXR activation	0.73	0.017
FXR/RXR activation	0.71	0.016
Circadian rhythm signaling	0.70	0.029
9 months
GDP-l-fucose biosynthesis I (from GDP-d-mannose)	1.65	0.500
Estrogen-mediated S-phase entry	1.47	0.077
Glioblastoma multiforme signaling	1.45	0.031
p53 signaling	1.44	0.036
Methylmalonyl pathway	1.36	0.250
PI3K/AKT signaling	1.30	0.033
2-Oxobutanoate degradation I	1.26	0.200
Cell cycle regulation by BTG family proteins	1.19	0.054
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	1.18	0.167
nNOS signaling in skeletal muscle cells	1.13	0.050
Bladder cancer signaling	1.13	0.035
Phosphatidylcholine biosynthesis I	1.12	0.143
tRNA splicing	1.11	0.049
Ovarian cancer signaling	1.11	0.028
Role of p14/p19ARF in tumor suppression	1.09	0.048
Phosphatidylethanolamine biosynthesis II	1.06	0.125
Gustation pathway	1.05	0.027
GABA receptor signaling	1.05	0.032
Role of Oct4 in mammalian embryonic stem cell pluripotency	1.04	0.044