Table 1.

Pro-erectile therapy algorithm

Patient preference		Low invasiveness			High invasiveness
Patient goal		Long-term penile health			Short-term erectile function
PCa treatment status		BNS	UNS	NNS	BNS	UNS	NNS
Surgery	Pharmaceutical approach	Daily and PRN full-dose PDE5i	PRN use of full-dose PDE5i	MUSE	ICI	ICI	ICI
	Mechanical approach	VED	VED	VED	VED	VED	VED
Radiation	Pharmaceutical approach	Daily and PRN full-dose PDE5i				ICI
	Mechanical approach		VED			VED

Baseline recommendation for all patients: Regular sexual activity (at least once a week). When applicable, patient’s partners should be included in the treatment plan. BNS: bilateral nerve sparing; ICI: intracavernous injection; NNS: non-nerve sparing; PC: prostate cancer; PDE5i: phosphodiesterase type 5 inhibitors; UNS: unilateral nerve sparing; VED: vacuum erection devices.