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. 2019 Sep 4;10:2062. doi: 10.3389/fmicb.2019.02062

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Copyright © 2019 Le Govic, Papon, Le Gal, Bouchara and Vandeputte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximum likelihood phylogenetic tree (PhyML + LG model) from reduced A-domain dataset. Bootstrap values greater than 50% are shown below branches. This analysis shows several clades which globally superimpose with the biological function, i.e., epidithiodioxopiperazines (ETP), extracellular siderophores (eSID), intracellular siderophores (iSID), cyclopeptides (CYCLO) and other unassigned NRPSs. Among the few discrepancies, both A-domains of sidE and pesH cluster with intracellular siderophores A-domains, although these NRPSs are not involved in the biosynthesis of siderophores.