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. 2019 Sep 4;10:2062. doi: 10.3389/fmicb.2019.02062

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Copyright © 2019 Le Govic, Papon, Le Gal, Bouchara and Vandeputte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modular domain structure, substrate specificities and genomic organization of the different biosynthetic ETP-gene clusters. Shown are the ETP gene clusters in S. apiospermum in comparison to the gliotoxin, sirodesmin, acetylaranotin and thioclapurine clusters from A. fumigatus, L. maculans, A. terreus, and C. purpurea, respectively. Orientation of the arrows indicates the direction of transcription. Common ETP moiety genes present in all six clusters are identically colored. The “other” category contains genes encoding a zinc finger transcription factor (gliZ, sirZ, tcpZ), cytochrome P450 monooxygenases (gliF, ataF, sirB, sirE), prenyltransferases (sirD, tcpD), acetyltransferases (gliH, sirH, ataH), epimerases (sirQ, sirR, sirS), glutamyltransferases (gliK, tcpK), methyltransferases (gliM, gliN, sirM, sirN, ataM, tcpN), an oxidoreductase (sirO), a benzoate p-hydroxylase (ataY), and a hypothetical protein (ataL). Abbreviations: SAM MTase, S-adenosyl-L-methionine-dependent methyltransferase; Tri7 acetylTase, trichothecene 4-O-acetyltransferase.