Table 2a.

Univariable and multivariable analysis of the association between preoperative risk and biochemical recurrence in patients with adverse pathology. For example, the hazard ratio (HR) of 0.26 for extracapsular extension means that, amongst men with extracapsular extension, the hazard of recurrence was about two-thirds lower in men who had preoperative low-risk features in comparison to men with preoperative intermediate or high-risk disease.

Adverse Feature (Low-risk vs. Intermediate/High Risk)	Univariable		Multivariable
	HR (95% CI)	p value	HR (95% CI)	p value
Extracapsular extension	0.26 (0.22, 0.31)	<0.0001	0.49 (0.40, 0.59)	<0.0001
Seminal vesicle invasion	0.44 (0.30, 0.64)	<0.0001	0.65 (0.44, 0.96)	0.029
Pathologic Gleason 7+	0.25 (0.22, 0.29)	<0.0001	0.46 (0.39, 0.53)	<0.0001
Lymph node invasion	0.46 (0.25, 0.87)	0.016	0.47 (0.23, 0.95)	0.036