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. 2019 Aug 16;12(8):dmm040725. doi: 10.1242/dmm.040725

Fig. 1.

Fig. 1.

TLR-7 agonist Resiquimod induces myocarditis, thrombocytopenia and cardiac hemorrhage. Cardiac involvement in Resiquimod-treated mice was assessed macroscopically and by microscopic histopathology. (A,B) Example and quantification of macroscopic hemorrhagic lesions on hearts of Resiquimod-treated mice. (C) Representative micrographs of H&E-stained heart sections of Resiquimod-treated mice showing immune cell infiltration, edema and red blood cells in the myocardial interstitial space. Degree of RBC extravasation was scored on a scale from 0 to 3, where 0 indicates none and 3 is the most severe. (D) Full platelet count, percentage drop in platelet number from baseline, and changes in hemoglobin content in response to Resiquimod-treatment. Mann–Whitney test was used for semiquantitative scores, n=3 (ctrl), n=10 (treated); unpaired two-tailed Student's t-test for hematological analysis, n=3. Symbols represent individual animals. All data presented as mean±s.e.m. *P<0.05, ****P<0.001.