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. 2019 Aug 16;12(8):dmm040725. doi: 10.1242/dmm.040725

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Regional T₁ and T₂ mapping is strongly influenced by iron deposition in the tissue. Heart tissue damage was assessed by histology and MRI. (A) T₁ and T₂ maps illustrating heterogeneity of T₁ and T₂ relaxation times with regions of low T₁, T₂ (A₁) and high T₂ (A₂). (B) Corresponding areas of interest (A₁ and A₂) in paraffin-embedded heart sections stained with H&E, Picrosirius Red and Perls Prussian Blue. (C) Histograms of signal distribution of T₁ and T₂ indices from regions of interest A₁ and A₂.