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. 2019 Aug 15;8(8):bio042937. doi: 10.1242/bio.042937

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — HIF1α also regulates the growth and apoptosis of melanoma cells. (A,B) MTT assay, (C,E) wound healing assay and (D,F) transwell assay were used to examine WM35 or miRNA-138 knockdown (KD) WM35 cell proliferation, migration and invasion, respectively, in the presence of HIF1α siRNA (si-HIF1α). (G) Cell apoptosis rates of miRNA-138 knockdown WM35 cells following transfection si-HIF1α were detected by flow cytometry. (H) Western blot assay to detect E-cadherin and Vimentin expressions following si-HIF1α treatment after 48 h in A375 or miRNA-138 overexpressing A375 cells.