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. 2019 Aug 15;8(8):bio042937. doi: 10.1242/bio.042937

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — The upregulation of miRNA-138 and HIF1α inhibitor synergistically suppressed melanoma growth and metastasis. (A) Tumor growth curve from nude mice with incubation of WM35 or miRNA-138 knockdown (KD) WM35 cells (n=7 mice per group). (B) Tumor growth curve from nude mice with incubation of A375 or miRNA-138 overexpressing (OE) A375 cells. BAY 87-2243 was orally administered as a 2-week continuous infusion at 9 mg/kg/day beginning on the fourth day after incubation (n=6 mice per group). (C) Representative images of tumor metastases in nude mice after intravenous injections of A375 or miRNA-138 overexpressing A375 cells on the twenty-fifth day. BAY 87-2243 was orally administered as a 2-week continuous infusion at 9 mg/kg/day beginning on the fourth day after incubation. Dashed outlines indicate lung metastases. (D) Quantitative analysis of the entire weight of lungs from C. (E) Analysis of weight change in nude mice from B (n=6 mice per group). *P<0.05, **P<0.01, ***P<0.001 versus indicated group.