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. 2019 Jul 22;8(8):bio042895. doi: 10.1242/bio.042895

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Defects of the nervous system in Col4a2^{em1(IMPC)Wtsi} mutant mice. (A,B) Appearance of the forebrain in semitransparent volume models of head and neck. View from lateral (A) and ventral (B). Note the irregular structure of the surface depicted in the inset. (C,D) Controls. (E,F) Cystic structures in the cortex of telencephalon. Sagittal (E) (ventral to the right) and coronal (F) resections through HREM data. (G,H) Controls. (I,J) Surface irregularities (arrowheads) of the superolateral cortex of telencephalon. Sagittal (I) (ventral to the right) and coronal (J) resection through HREM data. (K,L) Controls. (M,N) Tissue protrusions (arrows) at the basal forebrain. Sagittal (M) (ventral to the right) and coronal (O) resection through HREM data. (O,P) Controls. (Q,R) Thickening of motoric portion of trigeminal nerve and haemorrhage in the trigeminal ganglion. Axial sections from cranial. Ventral on top. Top panel of R magnifies ganglion and nerve. Bottom panel serves as control. (S,T) Abnormal oculomotor nerve. Axial sections from cranial. Ventral on top. Top panel of T magnifies roots of the oculomotor nerve. Bottom panel serves as control. Abbreviations: cn3, oculomotor nerve; di, diencephalon; eb, eyeball; hb, hindbrain; ie, inner ear; le, lens; me, mesencephalon; mp, motoric portion of trigeminal nerve; nc, nasal cavity; or, orbit; p, pinna; pg, pituitary gland; pi, pineal gland; ro, roof of orbit; te, telencephalon; tg, trigeminal ganglion; ul, upper limb. Scale bars: 200 µm.