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. 2019 Sep 3;25:6605–6614. doi: 10.12659/MSM.914877

Figure 1.

Figure 1

Effects of a high-fat diet (HFD) on the renin-angiotensin system (RAS) and peripheral insulin resistance in C57BL/6J mice. (A–E) A high-fat diet (HFD) upregulated the activity of the RAS and the level of angiotensin II (Ang-II) type 1 receptors (AT1R) measured by enzyme-linked immunosorbent assay (ELISA). (F, G) HFD inhibited increased phosphorylation of AKT at Ser473 induced by insulin after quantitative densitometry of representative Western blots of the mouse liver. Results are presented as the mean ±SD. * P<0.05, ** P<0.01, *** P<0.001 vs. the normal diet (ND) group. # P<0.05, ## P<0.01, ### P<0.001.