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Global BCAA catabolic defect in lean PP2Cm KO mice. (A) Illustration of BCAA catabolic process with enzymes, intermediates, and derivatives. (B) Relative abundances of BCAAs and their corresponding metabolites in the plasma of wildtype (WT) and PP2Cm knockout (PP2Cm KO) mice (WT, n = 10; KO, n = 8). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.
