Table 2.
Risk of gastric adenocarcinoma in participants exposed to prediabetes or diabetes compared with normoglycaemic participants, stratified by covariates, expressed as hazard ratio (HR) and 95% confidence interval (CI)
| Stratified variable | Gastric adenocarcinoma | Crude modela | Multivariable modelb |
|---|---|---|---|
| Number | HR (95% CI) | HR (95% CI) | |
| Sex | |||
| Male | |||
| Normoglycemic | 82 | Reference | Reference |
| Prediabetes or diabetes | 45 | 0.81 (0.56–1.17) | 0.80 (0.55–1.16) |
| Female | |||
| Normoglycemic | 50 | Reference | Reference |
| Prediabetes or diabetes | 42 | 1.24 (0.82–1.88) | 1.20 (0.79–1.84) |
| Age at entry | |||
| ≤49.5 | |||
| Normoglycemic | 25 | Reference | Reference |
| Prediabetes or diabetes | 10 | 0.83 (0.39–1.77) | 0.90 (0.42–1.93) |
| >49.5 | |||
| Normoglycemic | 107 | Reference | Reference |
| Prediabetes or diabetes | 77 | 1.00 (0.75–1.35) | 0.98 (0.73–1.33) |
| Body mass index | |||
| ≤25.4 | |||
| Normoglycemic | 68 | Reference | Reference |
| Prediabetes or diabetes | 34 | 1.05 (0.70–1.60) | 1.05 (0.69–1.59) |
| >25.4 | |||
| Normoglycemic | 64 | Reference | Reference |
| Prediabetes or diabetes | 53 | 0.90 (0.62–1.30) | 0.90 (0.63–1.31) |
| Tobacco smoking status | |||
| Current smoker | |||
| Normoglycemic | 39 | Reference | Reference |
| Prediabetes or diabetes | 33 | 1.22 (0.77–1.95) | 1.21 (0.75–1.94) |
| Ex-smoker | |||
| Normoglycemic | 41 | Reference | Reference |
| Prediabetes or diabetes | 24 | 0.89 (0.54–1.48) | 0.81 (0.48–1.36) |
| Non-smoker | |||
| Normoglycemic | 50 | Reference | Reference |
| Prediabetes or diabetes | 26 | 0.78 (0.48–1.26) | 0.81 (0.50–1.32) |
aAge was used as the time scale
bAdjusted for sex, calendar year, BMI, tobacco smoking status and education level at baseline; age was used as the time scale