Table 1.
Clinicopathological features of the considered series according to CLDN18 status
| Variables | n (na) | CLDN18 negative (%) | CLDN18 positive (%) | p |
|---|---|---|---|---|
| Age (years), mean ± SD | 523 (13) | 69.3 ± 12.4 | 69.5 ± 12.0 | NS |
| Gender | NS | |||
| Male | 348 (7) | 237 (69.5) | 104 (30.5) | |
| Female | 175 (6) | 123 (72.8) | 46 (27.2) | |
| Localisation | NS | |||
| Stomach | 408 (11) | 279 (70.3) | 118 (29.7) | |
| GEC | 115 (2) | 81 (71.7) | 32 (28.3%) | |
| Gastric localisation | p = 0.016 | |||
| Antrum | 198 (4) | 145 (74.7) | 49 (25.3) | |
| Corpus | 191 (3) | 119 (63.3) | 69 (36.7) | |
| Tumour grading | NS | |||
| 1 | 71 (3) | 51 (75.0) | 17 (25.0) | |
| 2 | 204 (4) | 141 (70.5) | 59 (29.5) | |
| 3 | 248 (6) | 168 (69.4) | 74 (30.6) | |
| TNM staging | NS | |||
| I | 150 (4) | 115 (78.8) | 31 (21.2) | |
| II | 189 (4) | 125 (67.6) | 60 (32.4) | |
| III | 139 (3) | 92 (67.6) | 44 (32.4) | |
| IV | 45 (2) | 29 (67.4) | 14 (32.6) | |
| Lauren histotype | p = 0.009 | |||
| Intestinal | 291 (7) | 202 (71.1) | 82 (28.9) | |
| Diffuse | 117 (4) | 65 (57.5) | 48 (42.5) | |
| Ming histotype | NS | |||
| Infiltrative | 339 (9) | 217 (65.8) | 113 (34.2) | |
| Expanding | 69 (2) | 50 (74.6) | 17 (25.4) |
n number of cases, na data not available for CLDN18 expression, GEC gastro-oesophageal carcinoma, NS not significant, CLDN18 Claudin-18, TNM tumour, node, metastasis