Table 2.
Association between CLDN18 status and the other biomarkers in primary tumours (NS = not significant)
| Biomarker | CLDN18 negative (%) | CLDN18 positive (%) | p |
|---|---|---|---|
| EBER | p < 0.001 | ||
| Positive | 6 (30.0) | 14 (70.0) | |
| Negative | 348 (71.0) | 142 (29.0) | |
| p53 | NS | ||
| Aberrant | 130 (68.8) | 59 (31.2) | |
| Normal | 220 (69.2) | 98 (30.8) | |
| p16 | NS | ||
| Positive | 177 (74.1) | 87 (25.9) | |
| Negative | 172 (65.2) | 68 (34.8) | |
| MMR | NS | ||
| Deficient | 75 (66.4) | 38 (33.6) | |
| Proficient | 273 (68.8) | 124 (31.2) | |
| E-cadherin | NS | ||
| Positive | 323 (70.4) | 136 (29.6) | |
| Negative | 41 (80.4) | 10 (19.6) | |
| HER2 | NS | ||
| Amplified | 48 (76.2) | 15 (23.8) | |
| Not amplified | 321 (71.8) | 126 (28.2) |
CLDN18 Claudin-18