Fig. 2.

Relationship between tumour CD8⁺ cell density, colorectal cancer recurrence, and overall survival in pooled QUASAR2 and VICTOR studies. Multivariable-adjusted hazard ratios for a colorectal cancer recurrence and b overall survival according to tumour (log2 transformed) CD8⁺ cell density (i.e. each unit change represents a two-fold increase or decrease in CD8⁺ cell density). Hazard ratio is shown relative to the recurrence risk of tumours with CD8⁺ cell density at the median of the pooled study populations. Corresponding Kaplan–Meier plots for colorectal cancer recurrence (c) and overall survival (d) for tumours with high and low CD8⁺ cell density using a cut point at the sample median. Shaded area in panels indicates 95% confidence interval (95% CI) for estimate of hazard ratio/survival function. P values in c, d were obtained by the Log-rank test