Table 1.
Associations between VD in three tumour compartments and clinico-pathological characteristics in the discovery cohort
| Tumour centre | Invasive margin | Peritumoral stroma | |||||||
|---|---|---|---|---|---|---|---|---|---|
| VDSCT number (percent) | VDSIM number (percent) | VDSPeri number (percent) | |||||||
| Characteristic | Low | High | p | Low | High | p | Low | High | p |
| Age (years) | |||||||||
| <66 | 66 (23.4) | 56 (19.9) | 0.279 | 68 (23.9) | 62 (21.8) | 0.476 | 41 (23.3) | 42 (23.9) | 1.000 |
| ≥66 | 75 (26.6) | 85 (30.1) | 74 (26.0) | 81 (28.4) | 47 (26.7) | 46 (26.1) | |||
| Sex | |||||||||
| Male | 69 (24.4) | 78 (27.7) | 0.340 | 69 (24.2) | 74 (26.0) | 0.636 | 44 (25.0) | 43 (24.4) | 1.000 |
| Female | 72 (25.5) | 63 (22.3) | 73 (25.6) | 69 (24.2) | 44 (25.0) | 45 (25.6) | |||
| Tumour site | |||||||||
| Proximala | 74 (26.2) | 75 (26.6) | 1.000 | 80 (28.1) | 83 (29.1) | 0.811 | 47 (26.7) | 50 (28.4) | 0.762 |
| Distal | 67 (23.8) | 66 (23.4) | 62 (21.8) | 60 (21.1) | 41 (23.3) | 38 (21.6) | |||
| Mismatch-repair status | |||||||||
| MMR proficient | 108 (41.1) | 118 (44.9) | 0.216 | 110 (41.4) | 106 (39.8) | 0.638 | 62 (38.3) | 65 (10.5) | 0.850 |
| MMR deficient | 22 (8.4) | 15 (5.7) | 23 (8.6) | 27 (10.2) | 18 (11.1) | 17 (10.5) | |||
| TS expression | |||||||||
| High | 103 (36.5) | 110 (39.0) | 0.406 | 106 (37.2) | 111 (38.9) | 0.581 | 70 (39.8) | 67 (38.1) | 0.717 |
| Low | 38 (13.5) | 31 (11.0) | 36 (12.6) | 32 (11.2) | 18 (10.2) | 21 (11.9) | |||
| Stage | |||||||||
| II | 57 (20.2) | 60 (21.3) | 0.809 | 51 (17.9) | 66 (23.2) | 0.092 | 32 (18.2) | 41 (23.3) | 0.221 |
| III | 84 (29.8) | 81 (28.7) | 91 (31.9) | 77 (27.0) | 56 (31.8) | 47 (26.7) | |||
| Adjuvant chemotherapy | |||||||||
| Yes | 71 (25.2) | 72 (25.5) | 1.000 | 77 (27.0) | 73 (25.6) | 0.636 | 47 (26.7) | 44 (25.0) | 0.763 |
| No | 70 (24.8) | 69 (24.5) | 65 (22.8) | 70 (24.6) | 41 (23.3) | 44 (25.0) | |||
| Invasive border configuration | |||||||||
| Pushing | 32 (12.2) | 64 (25.2) | <0.001 | 30 (11.7) | 69 (26.8) | <0.001 | 29 (18.1) | 43 (26.9) | 0.098 |
| Intermediate | 29 (11.4) | 29 (11.4) | 24 (9.3) | 34 (13.2) | 22 (13.8) | 19 (11.9) | |||
| Infiltrative | 61 (24.0) | 40 (15.7) | 71 (27.6) | 29 (11.3) | 28 (17.5) | 19 (11.9) | |||
| Budding | |||||||||
| Low | 79 (31.6) | 106 (42.4) | 0.021 | 76 (30.0) | 107 (42.3) | <0.001 | 58 (37.2) | 59 (37.8) | 1.0 |
| High | 39 (15.6) | 26 (10.4) | 47 (18.6) | 23 (9.1) | 20 (12.8) | 19 (12.2) | |||
| Grade of differentiation | |||||||||
| Well (G1) | 10 (3.7) | 17 (6.3) | 0.279 | 10 (3.7) | 15 (5.5) | 0.415 | 10 (6.0) | 9 (5.4) | 0.599 |
| Moderate (G2) | 97 (36.1) | 95 (35.3) | 95 (34.9) | 91 (33.5) | 54 (32.3) | 55 (32.9) | |||
| Poor (G3) | 28 (10.4) | 22 (8.2) | 34 (12.5) | 27 (9.9) | 23 (13.8) | 16 (9.6) | |||
| Relapse | |||||||||
| No | 148 (67.3) | 45 (72.6) | 0.536 | 93 (63.3) | 98 (71.0) | 0.169 | 37 (61.7) | 85 (73.3) | 0.124 |
| Yes | 72 (32.7) | 17 (27.4) | 54 (36.7) | 40 (29.0) | 23 (38.3) | 31 (26.7) | |||
VDS stroma-normalised vessel density (vessels per mm2), p p-value, TS thymidylate synthase. Pearson chi-square test was used for statistical analysis
a—to splenic flexure