Table 2.
Multivariable analyses including VDSIM, MMR, TS, gender, age and stage for TTR in colon cancer patients treated with surgery alone (A) or with adjuvant chemotherapy (B)
| Covariates | HR | 95.0% CI for HR | p-value | |
|---|---|---|---|---|
| Lower | Upper | |||
| A) Surgery-alone group | ||||
| VDSIM (high vs low) | 0.968 | 0.567 | 1.655 | 0.906 |
| MMR status (proficient vs deficient) | 1.762 | 0.747 | 4.157 | 0.196 |
| TS expression (high vs low) | 1.881 | 0.965 | 3.666 | 0.064 |
| Gender (women vs men) | 1.137 | 0.657 | 1.968 | 0.647 |
| Age (66 years or older) | 1.345 | 0.777 | 2.329 | 0.289 |
| Stage (III vs II) | 3.500 | 1.830 | 6.692 | <0.001 |
| B) Adjuvant chemotherapy group | ||||
| VDSIM (high vs low) | 0.473 | 0.256 | 0.873 | 0.017 |
| MMR status (proficient vs deficient) | 1.307 | 0.579 | 2.949 | 0.520 |
| TS expression (high vs low) | 1.279 | 0.635 | 2.578 | 0.491 |
| Gender (women vs men) | 0.785 | 0.430 | 1.434 | 0.430 |
| Age (66 years or older) | 0.750 | 0.427 | 1.319 | 0.318 |
| Stage (III vs II) | 1.583 | 0.845 | 2.965 | 0.152 |
MMR DNA mismatch-repair status, TS thymidylate synthase, HR hazard ratio, CI confidence interval. Cox-regression model was used for statistical analysis