Fig. 5.

In silico analysis of crenolanib target proteins. Crenolanib target proteins with an effective inhibition (EI%) of ≥50% with 5 μM crenolanib were retrieved from proteomicsDB (https://www.proteomicsdb.org) and subject to network analysis via STRING (a) and enrichment analysis using DAVID (b) as described in materials and methods. a Protein-protein interaction data from STRING were visualised in Cytoscape where the node colours reflect the EI% and the thickness of the edges indicate confidence levels of the interaction. b Enrichment of functional clusters for the Reactome database