Fig. 1.

Pooled data from three independent experiments showing OCICx 20 regression and regrowth with RT/RTCT (30 Gy over 3 weeks) and concurrent plerixafor for 3 weeks: no treatment controls (black), plerixafor alone (orange), RT alone (blue), RTCT (red), RTCT and concurrent plerixafor (purple). Each experiment included 5–12 mice per treatment arm. Each data point represents the mean tumour volume in up to 20 mice. A smoothed line was obtained for each treatment group using the ‘loess’ function in R.³⁴ Also shown are the mean tumour volume 95% confidence intervals for the RT, RTCT and RTCT + plerixafor arms. Tumour size was monitored after treatment using weekly CT imaging and volume was estimated using orthogonal tumour dimensions, assuming an elliptical shape. Time was measured from the start of treatment. RT, Radiotherapy; RTCT, Radiotherapy and concurrent cisplatin