Fig. 1.

Establishment of the trabectedin-resistant xenograft. ML017-bearing mice were treated with repeated cycles of trabectedin 0.15 mg/kg q7dx3 (orange arrows). Re-transplantation in four different sets of mice and a total of ten cycles of treatment (30 doses) were necessary to obtain a resistant model (a). The acquired resistance did not increase with additional treatments (b) and was maintained after eight passages without trabectedin (c). Blue: vehicles. Orange: trabectedin