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. 2019 Sep 4;2019(9):CD005049. doi: 10.1002/14651858.CD005049.pub5

Comparison 5. Metoprolol versus placebo or no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All‐cause mortality – main analysis 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 2.02 [0.37, 11.05]
2 All‐cause mortality – intention to treat (ITT) worse case: missing participants counted as events 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.41, 1.43]
3 All‐cause mortality – sensitivity analysis: persistent atrial fibrillation 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 2.02 [0.37, 11.05]
4 All‐cause mortality – sensitivity analysis: low risk of bias studies 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 2.02 [0.37, 11.05]
5 All‐cause mortality – sensitivity analysis: studies > 200 participants 1 394 Risk Ratio (M‐H, Fixed, 95% CI) 7.0 [0.36, 134.63]
6 Withdrawals due to adverse effects – main analysis 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 3.47 [1.48, 8.15]
7 Withdrawals due to adverse effects – sensitivity analysis: persistent atrial fibrillation 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 3.47 [1.48, 8.15]
8 Withdrawals due to adverse effects – sensitivity analysis: low risk of bias studies 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 3.47 [1.48, 8.15]
9 Withdrawals due to adverse effects – sensitivity analysis: studies > 200 participants 1 394 Risk Ratio (M‐H, Fixed, 95% CI) 3.33 [1.37, 8.12]
10 Proarrhythmia – main analysis 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 18.14 [2.42, 135.66]
11 Proarrhythmia – sensitivity analysis: persistent atrial fibrillation 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 18.14 [2.42, 135.66]
12 Proarrhythmia – sensitivity analysis: low risk of bias studies 2 562 Risk Ratio (M‐H, Fixed, 95% CI) 18.14 [2.42, 135.66]
13 Proarrhythmia – sensitivity analysis: studies > 200 participants 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
14 Atrial fibrillation recurrence – main analysis 2 562 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.68, 1.02]
15 Atrial fibrillation recurrence – sensitivity analysis: persistent atrial fibrillation 2 562 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.68, 1.02]
16 Atrial fibrillation recurrence – sensitivity analysis: low risk of bias studies 2 562 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.68, 1.02]
17 Atrial fibrillation recurrence – sensitivity analysis: studies > 200 participants 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only