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. 2019 Sep 4;2019(9):CD005049. doi: 10.1002/14651858.CD005049.pub5

Comparison 7. Dofetilide versus placebo or no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All‐cause mortality – main analysis 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.76, 1.27]
2 All‐cause mortality – intention to treat (ITT) worse case: missing participants counted as events 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 1.02 [0.79, 1.31]
3 All‐cause mortality – sensitivity analysis: persistent atrial fibrillation 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.76, 1.27]
4 All‐cause mortality – sensitivity analysis: low risk of bias studies 1 506 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.77, 1.29]
5 All‐cause mortality – sensitivity analysis: studies > 200 participants 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.76, 1.27]
6 Withdrawals due to adverse effects – main analysis 2 677 Risk Ratio (M‐H, Fixed, 95% CI) 1.77 [0.75, 4.18]
7 Withdrawals due to adverse effects – sensitivity analysis: persistent atrial fibrillation 2 677 Risk Ratio (M‐H, Fixed, 95% CI) 1.77 [0.75, 4.18]
8 Withdrawals due to adverse effects – sensitivity analysis: studies > 200 participants 2 677 Risk Ratio (M‐H, Fixed, 95% CI) 1.77 [0.75, 4.18]
9 Proarrhythmia – main analysis 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 5.50 [1.33, 22.76]
10 Proarrhythmia – sensitivity analysis: persistent atrial fibrillation 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 5.50 [1.33, 22.76]
11 Proarrhythmia – sensitivity analysis: low risk of bias studies 1 506 Risk Ratio (M‐H, Fixed, 95% CI) 9.29 [0.50, 171.62]
12 Proarrhythmia – sensitivity analysis: studies > 200 participants 3 1183 Risk Ratio (M‐H, Fixed, 95% CI) 5.50 [1.33, 22.76]
13 Atrial fibrillation recurrence – main analysis 3 1183 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.61, 0.85]
14 Atrial fibrillation recurrence – sensitivity analysis: persistent atrial fibrillation 3 1183 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.61, 0.85]
15 Atrial fibrillation recurrence – sensitivity analysis: low risk of bias studies 1 506 Risk Ratio (M‐H, Fixed, 95% CI) 0.62 [0.54, 0.70]
16 Atrial fibrillation recurrence – sensitivity analysis: studies > 200 participants 3 1183 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.61, 0.85]