1 All‐cause mortality – main analysis |
3 |
6071 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.86 [0.68, 1.09] |
2 All‐cause mortality – intention to treat (ITT) worse case: missing participants counted as events |
3 |
6071 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.67, 1.07] |
3 All‐cause mortality – sensitivity analysis: persistent atrial fibrillation |
1 |
199 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.97 [0.04, 23.36] |
4 All‐cause mortality – sensitivity analysis: low risk of bias studies |
1 |
4628 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.84 [0.66, 1.07] |
5 All‐cause mortality – sensitivity analysis: studies > 200 participants |
2 |
5872 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.86 [0.68, 1.09] |
6 Withdrawals due to adverse effects – main analysis |
3 |
6071 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.58 [1.34, 1.85] |
7 Withdrawals due to adverse effects – sensitivity analysis: persistent atrial fibrillation |
1 |
199 |
Risk Ratio (M‐H, Fixed, 95% CI) |
14.51 [0.90, 234.74] |
8 Withdrawals due to adverse effects – sensitivity analysis: low risk of bias studies |
1 |
4628 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.57 [1.32, 1.87] |
9 Withdrawals due to adverse effects – sensitivity analysis: studies > 200 participants |
2 |
5872 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.53 [1.31, 1.80] |
10 Proarrhythmia – main analysis |
2 |
5872 |
Risk Ratio (M‐H, Random, 95% CI) |
1.95 [0.77, 4.98] |
11 Proarrhythmia – sensitivity analysis: low risk of bias studies |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
12 Proarrhythmia – sensitivity analysis: studies > 200 participants |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
13 Stroke – main analysis |
2 |
5872 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.66 [0.47, 0.95] |
14 Stroke – sensitivity analysis: studies > 200 participants |
2 |
5872 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.66 [0.47, 0.95] |
15 Atrial fibrillation recurrence – main analysis |
2 |
1443 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.80, 0.91] |
16 Atrial fibrillation recurrence – sensitivity analysis: persistent atrial fibrillation |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
17 Atrial fibrillation recurrence – sensitivity analysis: studies > 200 participants |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |