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. 2019 Sep 4;2019(9):CD005049. doi: 10.1002/14651858.CD005049.pub5

Comparison 8. Dronedarone versus placebo or no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All‐cause mortality – main analysis 3 6071 Risk Ratio (M‐H, Fixed, 95% CI) 0.86 [0.68, 1.09]
2 All‐cause mortality – intention to treat (ITT) worse case: missing participants counted as events 3 6071 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.67, 1.07]
3 All‐cause mortality – sensitivity analysis: persistent atrial fibrillation 1 199 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.04, 23.36]
4 All‐cause mortality – sensitivity analysis: low risk of bias studies 1 4628 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.66, 1.07]
5 All‐cause mortality – sensitivity analysis: studies > 200 participants 2 5872 Risk Ratio (M‐H, Fixed, 95% CI) 0.86 [0.68, 1.09]
6 Withdrawals due to adverse effects – main analysis 3 6071 Risk Ratio (M‐H, Fixed, 95% CI) 1.58 [1.34, 1.85]
7 Withdrawals due to adverse effects – sensitivity analysis: persistent atrial fibrillation 1 199 Risk Ratio (M‐H, Fixed, 95% CI) 14.51 [0.90, 234.74]
8 Withdrawals due to adverse effects – sensitivity analysis: low risk of bias studies 1 4628 Risk Ratio (M‐H, Fixed, 95% CI) 1.57 [1.32, 1.87]
9 Withdrawals due to adverse effects – sensitivity analysis: studies > 200 participants 2 5872 Risk Ratio (M‐H, Fixed, 95% CI) 1.53 [1.31, 1.80]
10 Proarrhythmia – main analysis 2 5872 Risk Ratio (M‐H, Random, 95% CI) 1.95 [0.77, 4.98]
11 Proarrhythmia – sensitivity analysis: low risk of bias studies 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
12 Proarrhythmia – sensitivity analysis: studies > 200 participants 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
13 Stroke – main analysis 2 5872 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.47, 0.95]
14 Stroke – sensitivity analysis: studies > 200 participants 2 5872 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.47, 0.95]
15 Atrial fibrillation recurrence – main analysis 2 1443 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.80, 0.91]
16 Atrial fibrillation recurrence – sensitivity analysis: persistent atrial fibrillation 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
17 Atrial fibrillation recurrence – sensitivity analysis: studies > 200 participants 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only