DAPHNE 2008.

Methods	RCT Single‐blind Loss to follow‐up reported: yes
Participants	Bradycardia‐tachycardia sinus node disease with history of several episodes of AF or AFl and needing a pacemaker AF type: 100% paroxysmal. n = 135 Men: 49.6% Age (mean): 73 (SD 7) years Structural heart disease: 71%. LAD: 43 mm. LVEF: 56%
Interventions	Sotalol 167 mg/day (mean) vs beta‐blockers (atenolol or metoprolol) Method of AF cardioversion: 100% spontaneous Warfarin discretionary
Outcomes	At 19 months: Adverse effects AF recurrence
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomisation not described.
Allocation concealment (selection bias)	Unclear risk	Method of concealment not described.
Blinding (performance bias and detection bias) All outcomes	High risk	Single‐blind study.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Few participants were lost to follow‐up, were well balanced and well reported.
Selective reporting (reporting bias)	Low risk	All prespecified outcomes of interest were reported.
Other bias	Unclear risk	Restrictive inclusion criteria: only people with the bradycardia–tachycardia form of sinus node disease requiring pacemaker implantation were included.