Lloyd 1984.

Methods	RCT Double‐blind Loss to follow‐up reported: yes
Participants	Persistent AF lasting 1 month to 3 years (mean duration: NS). n = 82 Men: 38 Age (mean): 46 (range 15–79) years Structural heart disease: 94%. LAD: NS. LVEF: NS
Interventions	Disopyramide 450 mg/day vs quinidine 1.4 g/day vs placebo Method of AF cardioversion: electrical Warfarin discretionary
Outcomes	At 6 months: Mortality Stroke Proarrhythmia Adverse effects AF recurrence
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants were "assigned after randomization", but method not described.
Allocation concealment (selection bias)	Unclear risk	Procedure to conceal allocations not described.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blind study. Both drugs tested and placebo were "identical in appearance".
Incomplete outcome data (attrition bias) All outcomes	Low risk	Few participants were lost to follow‐up and losses were well reported.
Selective reporting (reporting bias)	Low risk	All outcomes predefined in the study and all outcomes of interest expected were reported.
Other bias	Low risk	No other bias apparent.