PRODIS 1996.

Methods	RCT Double‐blind Loss to follow‐up reported: yes
Participants	Persistent AF (mean duration: 5 months). n = 56 Men: 68% Age (mean): 60 (SD 11) years Structural heart disease: 65%. LAD: 46 mm. LVEF: NS
Interventions	Disopyramide 750 mg/day vs propafenone 900 mg/day Method of AF cardioversion: electrical Warfarin discretionary
Outcomes	At 6 months: Mortality Proarrhythmia Adverse effects AF recurrence
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants "were randomly assigned", but method not described.
Allocation concealment (selection bias)	Unclear risk	Method of concealment not described.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blind, double‐dummy employed.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No participant lost to follow‐up.
Selective reporting (reporting bias)	Low risk	All outcomes predefined in the study and all outcomes of interest expected were reported.
Other bias	Low risk	No other bias apparent.