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. 2019 Sep 4;2019(9):CD005049. doi: 10.1002/14651858.CD005049.pub5

PRODIS 1996.

Methods RCT
Double‐blind
Loss to follow‐up reported: yes
Participants Persistent AF (mean duration: 5 months). n = 56
Men: 68%
Age (mean): 60 (SD 11) years
Structural heart disease: 65%. LAD: 46 mm. LVEF: NS
Interventions Disopyramide 750 mg/day vs propafenone 900 mg/day
Method of AF cardioversion: electrical
Warfarin discretionary
Outcomes At 6 months:
Mortality
Proarrhythmia
Adverse effects
AF recurrence
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Participants "were randomly assigned", but method not described.
Allocation concealment (selection bias) Unclear risk Method of concealment not described.
Blinding (performance bias and detection bias) 
 All outcomes Low risk Double‐blind, double‐dummy employed.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No participant lost to follow‐up.
Selective reporting (reporting bias) Low risk All outcomes predefined in the study and all outcomes of interest expected were reported.
Other bias Low risk No other bias apparent.