Vitolo 1981.
Methods | RCT Open‐label Loss to follow‐up reported: yes |
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Participants | Any persistent AF (mean duration: NS). n = 54 Men: 37% Age (mean): 53 (SD 11) years Structural heart disease: 100%. LAD: NS. LVEF: NS |
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Interventions | Amiodarone 400 mg/day vs quinidine 1.2 g/day Method of AF cardioversion: electrical Warfarin discretionary |
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Outcomes | At 6 months: Mortality Proarrhythmia Adverse effects AF recurrence |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random numbers table. |
Allocation concealment (selection bias) | Unclear risk | Method of concealment not described. |
Blinding (performance bias and detection bias) All outcomes | High risk | Open‐label study. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No participant was loss to follow‐up in this small study. |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes of interest and all expected outcomes were reported. |
Other bias | Low risk | No other bias apparent. |
AF: atrial fibrillation; AFl: atrial flutter; LAD: left atrium diameter; LVEF: left ventricle ejection fraction; n: number of participants included in the study; NS: not stated; RCT: randomised controlled trial; SD: standard deviation.