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. 2019 Sep 4;9:858. doi: 10.3389/fonc.2019.00858

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Copyright © 2019 Feng and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structures of androgens and antiandrogens. (A) Two main androgens, testosterone (T), and dihydrotestosterone (DHT). (B) First-generation antiandrogens, cyproterone acetate (Androcur), Flutamide (Eulexin), Bicalutamide (Casodex), Nilutamide (Nilandron). 2-hydroxyflutamide is the major active metabolite of flutamide in the body. (C) Representative second-generation antiandrogens, Enzalutamide (Xtandi), Apalutamide (Erleada), and Darolutamide (Nubeqa). Structures are adopted from Wikipedia.