Fig. 2.

QS communication during host-microbe interaction. The scheme illustrates the impact of P. aeruginosa 3O-C₁₂-HSL on the mammalian host at cellular and molecular levels. The model also shows that 3O-C₁₂-HSL can associate and target several membrane-associated proteins, e.g., scaffold IQGAP1, sensory T2R38, and nuclear PPAR, which promote interaction with signaling cascades and cellular processes. These are connected together by calcium signaling, homeostasis, and mitochondrial and cytoskeletal dynamics, for example, and govern transcriptional and proteomic responses.