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IQGAP1 as a human target of 3O-C12-HSL. a A pull-down approach with a biotin-conjugated 3O-C12-HSL probe and mass spectrometry-based proteomic analysis used to identify the target IQGAP1. For more details on methods, refer to Karlsson et al. [25]. b Schematic structure of IQGAP1 with several domains that interact with many different proteins and thereby regulate diverse cytoskeletal reorganization and cell signaling events.
