Table 3.
Univariable and multivariable Cox regression analyses for time to progression
| Univariable analysis |
Multivariable analysis |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Body composition variables | ||||||
| Low SMM | 1.33 | 1.02–1.74 | 0.033 | 1.35 | 1.01–1.81 | 0.042 |
| Low muscle density | 1.01 | 0.77–1.32 | 0.970 | |||
| Low TATI | 1.24 | 0.95–1.62 | 0.107 | |||
| Low SATI | 1.07 | 0.82–1.39 | 0.608 | |||
| Low VATI | 1.21 | 0.93–1.58 | 0.149 | |||
| Low visceral fat percentage | 1.14 | 0.87–1.48 | 0.325 | |||
| BMI ≥25 (ref: <25) | 0.92 | 0.70–1.20 | 0.543 | |||
| Low SMM and low TATIa | 1.57 | 1.15–2.14 | 0.005 | |||
| Other baseline variables | ||||||
| Female sex | 1.46 | 1.05–2.03 | 0.025 | 1.44 | 1.01–2.06 | 0.043 |
| Age >65 years | 0.82 | 0.63–1.07 | 0.146 | |||
| HBV | 1.45 | 1.02–2.05 | 0.037 | 1.36 | 0.94–1.96 | 0.103 |
| HCV | 0.91 | 0.63–1.32 | 0.621 | |||
| Alcohol | 0.84 | 0.64–1.11 | 0.224 | |||
| Child-Pugh B (ref: Child-Pugh A) | 1.59 | 1.04–2.43 | 0.031 | 1.50 | 0.97–2.31 | 0.070 |
| ECOG PS (ref: ECOG PS 0) | 0.027 | |||||
| ECOG PS 1 | 1.07 | 0.80–1.42 | 0.97 | 0.72–1.30 | ||
| ECOG PS 2 | 1.96 | 1.19–3.22 | 1.63 | 0.96–2.78 | ||
| BCLC stage Cb (ref: B) | 1.50 | 1.10–2.06 | 0.012 | |||
| Number of nodes (ref: 1 node) | 0.408 | |||||
| 2–3 nodes | 1.13 | 0.77–1.66 | ||||
| >3 nodes/diffuse infiltrating | 1.27 | 0.88–1.83 | ||||
| Tumor size >70 mm | 1.35 | 1.04–1.76 | 0.025 | 1.10 | 0.82–1.48 | 0.524 |
| Macroscopic vascular invasion | 1.46 | 1.12–1.91 | 0.005 | 1.37 | 1.03–1.81 | |
| Presence of extrahepatic metastases (ref: none) | 0.208 | |||||
| Lymph nodes | 1.28 | 0.93–1.78 | ||||
| Other organ | 1.27 | 0.93–1.74 | ||||
| Received previous treatments | 0.81 | 0.62–1.05 | 0.114 | |||
| High NLRc | 1.81 | 1.16–2.83 | ||||
| AFP ≥400 ng/mL | 1.74 | 1.32–2.28 | <0.001 | 1.84 | 1.37–2.46 | <0.001 |
AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer classification; BMI, body mass index; ECOG PS, Eastern Cooperative Oncology Group performance status; HBV, hepatitis B virus; HCV, hepatitis C virus; SATI, subcutaneous adipose tissue index; SMM, skeletal muscle mass; TATI, total adipose tissue index; VATI, visceral adipose tissue index.
a
Not included in multivariable analysis due to collinearity with low SMM (model shown in online suppl. Table 2).
b
Not included in multivariable analysis to reduce overlapping variance (multicollinearity).
c
Not included in multivariable analysis due to large numbers of missing values (n = 179)