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Knockdown of c-FLIPL enhanced the efficacy of PD-1 blockade in vivo. (A) C57/B6 mice were injected subcutaneously with B16-c-FLIP-shRNA and B16-c-FLIP-control stable cells. After the treatment with PD-1 blockade, tumors were extracted and photographed. (B) Tumor growth curves of C57BL/6 mice. Tumor volumes were calculated at the indicated time points. (C) Tumor weights on the 14th day. Results are mean volume ± sem for 8 mice per group per time point. *P < 0.05 (Student's t-test).
