Skip to main content
. 2019 Sep 4;9:851. doi: 10.3389/fonc.2019.00851

Figure 1.

Figure 1

LOD as a function of coverage depth according to the binomial distribution. Coverage depth needed to maintain an intended LOD (within 3–20% VAF range) for three cumulative probability settings: for false positive probability of 0.001 and true positive of 0.999, a LOD of 20% is achieved at 61 coverage depth, a LOD of 10% at 175, a LOD of 5% at 562, and a LOD of 3% at 1,650. For the false positive probability of 0.010 and true positive of 0.990, a LOD of 20% is achieved at 31, a LOD of 10% at 81, a LOD of 5% at 288, and a LOD of 3% at 886 coverage depth, respectively. For the false positive probability of 0.050 and true positive of 0.950, a LOD of 20% is achieved at 30, a LOD of 10% at 30, a LOD of 5% at 124, and a LOD of 3% at 392 coverage depth, respectively.