Fig. 2.

a Tumor size at the first detection by B-mode US or Kupffer phase CEUS without EOB-MRI or MDCT in the cohort (n = 54). The maximum size of initially detected HCC nodules was significantly smaller in the surveillance arm with Kupffer phase CEUS with reinjection (16.7 ± 6.2 mm [9–32 mm]) than with the B-mode US (13.0 ± 4.1 mm [6–25 mm]) (p = 0.011). b Tumor size at the first detection by hepatitis virus type. There was a significant difference in tumor size in HCV-related HCC (p = 0.012); however, no significant difference was observed in HBV-related HCC (p = 0.715).