Table 1.
Baseline demographic and clinical characteristics of the CEUS and the B-mode US group
| Characteristics | CEUS (n = 309) | B-mode US (n = 313) | p value |
|---|---|---|---|
| Age, years | |||
| Median (range) | 68.0 (61.0–75.0) | 67.0 (58.0–74.0) | 0.200 |
| Mean ± SD | 66.9±10.2 | 65.7±11.2 | 0.152 |
| Gender, males/females | 136/173 | 132/181 | 0.643 |
| Etiology | 0.639 | ||
| HBV (NA+) | 78 | 85 | |
| HBV(nA-) | 23 | 18 | |
| HCV | 208 | 210 | |
| Median albumin (range), mg/dL | 3.9 (3.6–4.3) | 4.0 (3.6–4.3) | 0.676 |
| Median bilirubin (range), mg/dL | 0.90 (0.70–1.20) | 0.81 (0.70–1.17) | 0.360 |
| Median PT (range), INR | 1.09 (1.02–1.17) | 1.08 (1.01–1.16) | 0.247 |
| Median PT (range), % | 85.0 (75.0–96.7) | 85.5 (76.5–98.7) | 0.347 |
| Encephalopathy | 0.684 | ||
| None | 306 | 311 | |
| Grades I, II | 3 | 2 | |
| Grades III, IV | 0 | 0 | |
| Ascites | 0.114 | ||
| None | 293 | 285 | |
| Mild | 15 | 27 | |
| Moderate | 1 | 1 | |
| Child-Pugh score | 0.826 | ||
| 5 | 206 | 198 | |
| 6 | 58 | 67 | |
| 7 | 15 | 16 | |
| 8 | 5 | 8 | |
| 9 | 3 | 3 | |
| 10 | 1 | 0 | |
| Median AFP (range), ng/dL | 6.6 (3.1–14.0) | 6.5 (3.4–16.8) | 0.945 |
| Median AFP-3 (range), % | 1.6 (0.0–6.2) | 1.2 (0.0–5.1) | 0.597 |
| Median PIVKA-II (DCP) (range), mAU/mL | 19.0 (15.0–24.0) | 18.0 (14.0–24.0) | 0.327 |
| Median hyaluronic acid (range), ng/mL | 203 (88–420) | 198 (98–394) | 0.955 |
| Median platelet count (range), × 10µ/L | 9.7 (7.4–11.8) | 10.1 (7.6–12.0) | 0.394 |
| Median AST (range), IU/L | 44.0 (31.0–61.0) | 41.0 (28.0–59.5) | 0.126 |
| Median ALT (range), IU/L | 35.0 (23.5–50.0) | 33.0 (22.0–52.5) | 0.226 |