Table 3.
Association between K19 expression status and other markers
| Variable | All (n = 125) n (%) | K19-deficient HCC (n = 96) n (%) | K19-proficient HCC (n = 29) n (%) | p value |
|---|---|---|---|---|
| E-cadherin | ||||
| Proficient | 106 (85) | 85 (89) | 21 (72) | 0.043 |
| Deficient | 19 (15) | 11(12) | 8 (28) | |
| Vimentin | ||||
| Proficient | 8 (6) | 4 (4) | 4 (14) | 0.084 |
| Deficient | 117 (94) | 92 (96) | 25 (86) | |
| K7 | ||||
| Proficient | 43 (34) | 28 (29) | 15 (52) | 0.043 |
| Deficient | 82 (66) | 68 (71) | 14 (48) | |
| NOTCH-1 | ||||
| Proficient | 72 (58) | 55 (57) | 17 (59) | 1.00 |
| Deficient | 53 (42) | 41 (43) | 12 (41) | |
| HepPar-1 | ||||
| Proficient | 90 (72) | 74 (77) | 16 (55) | 0.033 |
| Deficient | 35 (28) | 22 (23) | 13 (45) | |
| Arginase-1 | ||||
| Proficient | 87 (70) | 76 (79) | 11 (34) | <0.0001 |
| Deficient | 38 (30) | 20 (21) | 18 (66) | |
| LINE-1 methylation ratio | ||||
| Mean % (95% CI) | 53.3 (48.6–58.1) | 60.3 (52.0–68.6) | ||
| 55% or more | 59 (50) | 40 (43) | 19 (73) | 0.0079* |
| Under55% | 60 (50) | 53 (57) | 7 (27) | |
| Not analyzed | 6 | 3 | 3 | |